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Katzung & Trevor's. Pharmacology. Examination. & Board Review a LANGE medical book. New York Chicago San Francisco Athens London Madrid Mexico City. Katzung & Trevor's Pharmacology: Examination & Board Review, 12e. Bertram G. Katzung, Marieke Kruidering-Hall, Anthony J. Trevor. Go to Review Questions. a LANGE medical book Katzung & Trevor's Pharmacology Examination & Board Review Eleventh Edition Anthony J. Trevor, PhD Professor Emeritus of.

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Katzung's Pharmacology: Examination and Board Review: Medicine & Health Science Books @ ppti.info From the authors of pharmacology's most trusted textbook, Katzung & Trevor's Basic & Clinical Pharmacology, this full-color resource delivers a clear, concise. CODE: Download PDF Katzung & Trevor's Pharmacology Examination and Board Review 11th Edition (Katzung & Trevor's.

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Katzung & Trevor's Pharmacology: Examination & Board Review, 12e

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Katzung & Trevor's Pharmacology Examination and Board Review 10th Edition Pdf

Peripheral 5-HT1 receptors mediate both excitatory and inhibitory effects in various smooth muscle tissues. These receptors mediate synaptic excitation in the CNS and smooth muscle contraction gut, bronchi, uterus, some vessels or relaxation other vessels.

Several mechanisms are involved, including in different tissues increased IP3, decreased potassium conductance, and decreased cAMP. This receptor probably mediates some of the vasodilation, diarrhea, and bronchoconstriction that occur as symptoms of carcinoid tumor, a neoplasm that releases serotonin and other substances.

These receptors mediate excitation via a 5-HT-gated cation channel.

Antagonists acting at this receptor are extremely useful antiemetic drugs. Serotonin has no clinical applications, but other more selective agonists are useful.

They are the first-line treatment for acute migraine and cluster headache attacks, an observation that strengthens the association of serotonin abnormalities with these headache syndromes. These drugs are active orally; sumatriptan is also available for nasal and parenteral administration. Ergot alkaloids, discussed later, are partial agonists at some 5-HT receptors.

It activates receptors in the CNS and appears to moderately reduce appetite. Older drugs, fenfluramine and dexfenfluramine, appear to act directly and by releasing neuronal 5-HT or inhibiting SERT, and thereby activating central 5-HT2C receptors. They were withdrawn in the USA because their use was associated with damage to cardiac valves.Serotonin has no clinical applications, but other more selective agonists are useful.

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